(SCL), »leukoaraiosis» (LA) och »deep white-matter hyperintensities» (DWMH) har använts med varierande innebörd i olika artiklar. Olika författare har uppgett

Yuanjing's PhD project is on the interplay of the cerebral small vessel disease (e.g., white matter hyperintensities, brain atrophy, perivascular spaces, etc.)

In this chapter, we describe a case in which a diagnosis of CNS demyelination was highly suggested based on the appearance of white matter lesions identified on MRI. White matter hyperintensities (WMH), which are typically detected on fluid-attenuated inversion recovery (FLAIR) brain MRI, are common findings in older adults. WMH are considered a type of sporadic small vessel disease (Wardlaw and Pantoni, 2014). The aetiology and the pathophysiology of WMH are not yet completely understood. 2015-02-17 · White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small vessel disease, and can easily be detected on MRI. Over the past three decades, research has shown that the Se hela listan på verywellhealth.com 2020-01-01 · White matter hyperintensities (WMH) are white matter lesions in the brain that appear as high signal intensity regions on T2-weighted MRI. They have a number of possible pathological substrates including blood–brain barrier leakage, hypoperfusion, ischemia/hypoxia, inflammation, neurodegeneration and amyloid angiopathy (Gouw et al., 2011).

White matter hyperintensities

White matter hyperintensities and imaging patterns of brain ageing in the general population. Habes M, Erus G, Toledo JB, Zhang T, Bryan N, Launer LJ, Rosseel Y, Janowitz D, Doshi J, Van der Auwera S, von Sarnowski B, Hegenscheid K, Hosten N, Homuth G, Völzke H, Schminke U, Hoffmann W, Grabe HJ, Davatzikos C Brain 2016 Apr;139 (Pt 4):1164-79. Background: White matter hyperintensities, prevalent in patients with Parkinson's disease (PD), significantly affect parkinsonian motor symptoms. The objective of this study was to investigate the relationship between white matter hyperintensities and nigrostriatal dopamine depletion and their interaction or mediating effects on motor symptoms in patients with drug-naive early-stage PD. Se hela listan på ahajournals.org White Matter Hyperintensities White matter hyperintensities (WMHs) are the bright spots on T2-weighted brain MRI scans. They are very common in elderly individuals, they are more prevalent in people with high blood pressure and other vascular risk factors, and they are associated with poorer cognition. 2016-11-01 · White matter hyperintensities of presumed vascular origin (WMHs), also known as leukoariosis, white matter lesions, or white matter disease (Wardlaw et al., 2013), are common findings in MRI scans and appear hyperintense on T2-weighted, fluid attenuated inversion recovery (FLAIR), and proton density-weighted images.

“White matter disease” identifies a series of different conditions and pathological mechanisms: autoimmune, infectious, toxic-metabolic and vascular. Each of these leads to a global impairment of the neural myelination process through the secondary destruction of previously myelinated structures.

Background: White matter hyperintensities of presumed vascular origin (WMH) are one of the imaging features of cerebral small vessel disease. Controversies persist about the effects of WMH on cognitive dysfunction. White matter hyperintensities proliferate as the brain ages and are associated with increased risk for cognitive decline as well as Alzheimer’s disease and related dementias. As such, white matter hyperintensities have been targeted as a surrogate biomarker in intervention trials with older adults.

2017-05-26 · White matter hyperintensities (WMHs) are lesions in the brain that show up as areas of increased brightness when visualised by T2-weighted magnetic resonance imaging (MRI). WMH’s are also referred to as Leukoaraiosis and are often found in CT or MRI’s of older patients.

When it occurs in the basal ganglia part of the brain, this is called subcortical hyperintensities. Near lateral ventricles, a periventricular hyperintensity can be observed.

4 According to Charles DeCarli, the director of UC Davis Alzheimer's Disease Center, these areas may indicate some type of injury to the brain, perhaps due to decreased blood flow in that area. White matter hyperintensities can be caused by a variety of factors including ischemia, micro- hemorrhages, gliosis, damage to small blood vessel walls, breaches of the barrier between the cerebrospinal fluid and the brain, or loss and deformation of the myelin sheath. The effect of white matter hyperintensities on UPDRS total score and bradykinesia subscore was indirectly mediated by dopamine transporter availability in the posterior putamen, whereas the axial sub-score was directly affected by white matter hyperintensities.
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Scientists in 2011 are honing in on other possible links between white matter hyperintensity and a higher propensity for other human maladies like diabetes, Alzheimer's disease, strokes, multiple sclerosis and heart disease. White matter hyperintensities proliferate as the brain ages and are associated with increased risk for cognitive decline as well as Alzheimer’s disease and related dementias. As such, white matter hyperintensities have been targeted as a surrogate biomarker in intervention trials with older adults. 2010-07-26 · White matter hyperintensities were significantly associated with an increased risk of death both in the general population and in high risk populations with a history of stroke, depression, or minor neurological symptoms. This association could be mediated by an increased risk of stroke and dementia.

Methods A total of 69 migraineurs underwent MRI scans to evaluate WMHs For executive functions, neither the participants with depression within the first white matter hyperintensities tertile group (z-score difference −0.28, 95% CI −1.45 to 0.91, P = 0.643) nor those within the second white matter hyperintensities tertile differed from the reference group (z-score difference −0.77, 95% CI −2.18 to 0.64, P = 0.276; test for interaction: b = −0.50, 95% CI Objective To test the hypotheses that hypertension and nocturnal blood pressure are related to white matter hyperintensity (WMH) volume, an MRI marker of small vessel cerebrovascular disease, and that WMH burden statistically mediates the association of hypertension and dipping status with memory functioning, we examined the relationship of hypertension and dipping status on WMH volume and White matter hyperintensities are thought to be caused by small vessel infarcts (restriction in blood flow) in the white matter and ultimately result in impairment of brain functions, such as cognition, balance and gait, that depend on complicated interactions between regions. 11. Wen W, Sachdev PS, Li JJ, Chen X, Anstey KJ. White matter hyperintensities in the forties: their prevalence and topography in an epidemiological sample aged 44–48.
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2020-01-20 · CONCLUSION: We provide evidence for an association between baseline white matter hyperintensities and progression of frailty. Our findings add to a growing body of literature suggesting WMH is a marker for frailty. © The Author (s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.

However, their significance and correlation to migraine disease burden remain unclear. This study aims to examine the correlation of WMHs with migraine features and explore the relationship between WMHs and migraine prognosis. Methods A total of 69 migraineurs underwent MRI scans to evaluate WMHs For executive functions, neither the participants with depression within the first white matter hyperintensities tertile group (z-score difference −0.28, 95% CI −1.45 to 0.91, P = 0.643) nor those within the second white matter hyperintensities tertile differed from the reference group (z-score difference −0.77, 95% CI −2.18 to 0.64, P = 0.276; test for interaction: b = −0.50, 95% CI Objective To test the hypotheses that hypertension and nocturnal blood pressure are related to white matter hyperintensity (WMH) volume, an MRI marker of small vessel cerebrovascular disease, and that WMH burden statistically mediates the association of hypertension and dipping status with memory functioning, we examined the relationship of hypertension and dipping status on WMH volume and White matter hyperintensities are thought to be caused by small vessel infarcts (restriction in blood flow) in the white matter and ultimately result in impairment of brain functions, such as cognition, balance and gait, that depend on complicated interactions between regions. 11. Wen W, Sachdev PS, Li JJ, Chen X, Anstey KJ. White matter hyperintensities in the forties: their prevalence and topography in an epidemiological sample aged 44–48. Hum Brain Mapp 2009; 30:1155–1167 [Google Scholar] Stroke and white matter hyperintensities, for instance, share the same risk factors, DeCarli says. "Having these hyperintensities on your brain scan indicates that you are at risk for stroke." Referring to it as "the million-dollar question of my research," DeCarli has sought links between Alzheimer's disease and white matter hyperintensities.